The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice

The GCN2 eIF2α kinase is essential for activation of the general amino acid control pathway in yeast when one or more amino acids become limiting for growth. GCN2's function in mammals is unknown, but must differ, since mammals, unlike yeast, can synthesize only half of the standard 20 amino ac...

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Main Authors: Zhang, Peichuan, McGrath, Barbara C., Reinert, Jamie, Olsen, DeAnne S., Lei, Li, Gill, Sangeeta, Wek, Sheree A., Vattem, Krishna M., Wek, Ronald C., Kimball, Scot R., Jefferson, Leonard S., Cavener, Douglas R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC134046/
https://ncbi.nlm.nih.gov/pubmed/12215525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.19.6681-6688.2002
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