The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice

The GCN2 eIF2α kinase is essential for activation of the general amino acid control pathway in yeast when one or more amino acids become limiting for growth. GCN2's function in mammals is unknown, but must differ, since mammals, unlike yeast, can synthesize only half of the standard 20 amino ac...

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Bibliografiske detaljer
Main Authors: Zhang, Peichuan, McGrath, Barbara C., Reinert, Jamie, Olsen, DeAnne S., Lei, Li, Gill, Sangeeta, Wek, Sheree A., Vattem, Krishna M., Wek, Ronald C., Kimball, Scot R., Jefferson, Leonard S., Cavener, Douglas R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC134046/
https://ncbi.nlm.nih.gov/pubmed/12215525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.19.6681-6688.2002
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