The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice

The GCN2 eIF2α kinase is essential for activation of the general amino acid control pathway in yeast when one or more amino acids become limiting for growth. GCN2's function in mammals is unknown, but must differ, since mammals, unlike yeast, can synthesize only half of the standard 20 amino acids....

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Dettagli Bibliografici

Pubblicato in:	Mol Cell Biol
Autori principali:	Zhang, Peichuan, McGrath, Barbara C., Reinert, Jamie, Olsen, DeAnne S., Lei, Li, Gill, Sangeeta, Wek, Sheree A., Vattem, Krishna M., Wek, Ronald C., Kimball, Scot R., Jefferson, Leonard S., Cavener, Douglas R.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2002
Soggetti:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134046/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12215525/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.19.6681-6688.2002
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