The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice

The GCN2 eIF2α kinase is essential for activation of the general amino acid control pathway in yeast when one or more amino acids become limiting for growth. GCN2's function in mammals is unknown, but must differ, since mammals, unlike yeast, can synthesize only half of the standard 20 amino acids....

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Autores principales:	Zhang, Peichuan, McGrath, Barbara C., Reinert, Jamie, Olsen, DeAnne S., Lei, Li, Gill, Sangeeta, Wek, Sheree A., Vattem, Krishna M., Wek, Ronald C., Kimball, Scot R., Jefferson, Leonard S., Cavener, Douglas R.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 2002
Materias:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134046/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12215525/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.19.6681-6688.2002
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