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GCN2 Protein Kinase Is Required to Activate Amino Acid Deprivation Responses in Mice Treated with the Anti-cancer Agent l-Asparaginase

Asparaginase depletes circulating asparagine and glutamine, activating amino acid deprivation responses (AADR) such as phosphorylation of eukaryotic initiation factor 2 (p-eIF2) leading to increased mRNA levels of asparagine synthetase and CCAAT/enhancer-binding protein β homologous protein (CHOP) a...

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Main Authors: Bunpo, Piyawan, Dudley, Allison, Cundiff, Judy K., Cavener, Douglas R., Wek, Ronald C., Anthony, Tracy G.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781691/
https://ncbi.nlm.nih.gov/pubmed/19783659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.047910
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