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The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment

Asparaginase is an important drug in the treatment regimen for acute lymphoblastic leukemia. Asparaginase depletes circulating asparagine and glutamine, activating an amino acid stress response (AAR) involving phosphorylation of eukaryotic initiation factor 2 (eIF2) by general control nonderepressib...

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Bibliografske podrobnosti
Main Authors: Wilson, Gabriel J., Bunpo, Piyawan, Cundiff, Judy K., Wek, Ronald C., Anthony, Tracy G.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840205/
https://ncbi.nlm.nih.gov/pubmed/24002574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00080.2013
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