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The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment
Asparaginase is an important drug in the treatment regimen for acute lymphoblastic leukemia. Asparaginase depletes circulating asparagine and glutamine, activating an amino acid stress response (AAR) involving phosphorylation of eukaryotic initiation factor 2 (eIF2) by general control nonderepressib...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3840205/ https://ncbi.nlm.nih.gov/pubmed/24002574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00080.2013 |
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