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Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors
Synthetic inhibitors of protein-protein interactions are being discovered despite the inherent challenge in targeting large contact surfaces with small molecules. An analysis of available examples identifies common features of complexes that make them tractable for small molecules. We deduced that r...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2955827/ https://ncbi.nlm.nih.gov/pubmed/20712375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb1001747 |
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