Llwytho...
Engineered Protein Scaffolds as Leads for Synthetic Inhibitors of Protein-Protein Interactions
Rationally designed protein-protein interaction inhibitors mimic interfacial binding epitopes, specifically residues that contribute significantly to binding. However, direct mimicry often does not lead to high affinity ligands because the natural complexes themselves are functionally transient and...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Curr Opin Chem Biol |
|---|---|
| Prif Awduron: | , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5967659/ https://ncbi.nlm.nih.gov/pubmed/29803113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2018.05.013 |
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