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Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors

Synthetic inhibitors of protein-protein interactions are being discovered despite the inherent challenge in targeting large contact surfaces with small molecules. An analysis of available examples identifies common features of complexes that make them tractable for small molecules. We deduced that r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jochim, Andrea L., Arora, Paramjit S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955827/
https://ncbi.nlm.nih.gov/pubmed/20712375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb1001747
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