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Phosphatidylinositol 3-kinase (PI3K): The Oncoprotein
The catalytic and regulatory subunits of class I phosphoinositide 3-kinase (PI3K) have oncogenic potential. The catalytic subunit p110α and the regulatory subunit p85 undergo cancer-specific gain-of-function mutations that lead to enhanced enzymatic activity, ability to signal constitutively and onc...
Tallennettuna:
| Päätekijät: | , , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2011
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2955792/ https://ncbi.nlm.nih.gov/pubmed/20582532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/82_2010_80 |
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