Phosphatidylinositol 3-kinase (PI3K): The Oncoprotein

The catalytic and regulatory subunits of class I phosphoinositide 3-kinase (PI3K) have oncogenic potential. The catalytic subunit p110α and the regulatory subunit p85 undergo cancer-specific gain-of-function mutations that lead to enhanced enzymatic activity, ability to signal constitutively and onc...

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Bibliographic Details
Main Authors: Vogt, Peter K., Hart, Jonathan R., Gymnopoulos, Marco, Jiang, Hao, Kang, Sohye, Bader, Andreas G., Zhao, Li, Denley, Adam
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955792/
https://ncbi.nlm.nih.gov/pubmed/20582532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/82_2010_80
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