Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis

BACKGROUND: The mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene results in CF. The most common mutation, ΔF508-CFTR, is a temperature-sensitive, trafficking mutant with reduced chloride transport and exaggerated immune response. The ΔF508-CFTR is misfolded, ubiquitina...

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Autori principali: Vij, Neeraj, Min, Taehong, Marasigan, Rhul, Belcher, Christopher N, Mazur, Steven, Ding, Hong, Yong, Ken-Tye, Roy, Indrajit
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954907/
https://ncbi.nlm.nih.gov/pubmed/20868490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-3155-8-22
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