Inhibition of histone-deacetylase activity rescues inflammatory cystic fibrosis lung disease by modulating innate and adaptive immune responses

BACKGROUND: Chronic lung disease resulting from dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) and NFκB-mediated neutrophilic-inflammation forms the basis of CF-related mortality. Here we aimed to evaluate if HDAC inhibition controls Pseudomonas-aeruginosa-lipopolysaccharid...

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Publicado en:Respir Res
Main Authors: Bodas, Manish, Mazur, Steven, Min, Taehong, Vij, Neeraj
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2018
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5755330/
https://ncbi.nlm.nih.gov/pubmed/29301535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-017-0705-8
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