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Adapting Proteostasis and Autophagy for Controlling the Pathogenesis of Cystic Fibrosis Lung Disease

Cystic fibrosis (CF), a fatal genetic disorder predominant in the Caucasian population, is caused by mutations in the cystic fibrosis transmembrane conductance regulator (Cftr) gene. The most common mutation is the deletion of phenylalanine from the position-508 (F508del-CFTR), resulting in a misfol...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Bodas, Manish, Vij, Neeraj
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367269/
https://ncbi.nlm.nih.gov/pubmed/30774592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00020
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