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Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding

[Image: see text] Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor−DNA interfaces, and modulate gene expression pathways in cell culture experiments. In this paper we describe a high-resolutio...

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Bibliografiska uppgifter
Huvudupphovsmän: Chenoweth, David M., Dervan, Peter B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2010
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954530/
https://ncbi.nlm.nih.gov/pubmed/20812704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja105068b
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