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Oligomerization Route to Py-Im Polyamide Macrocycles

[Image: see text] Cyclic eight-ring pyrrole-imidazole polyamides are sequence-specific DNA-binding small molecules that are cell permeable and can regulate endogenous gene expression. Syntheses of cyclic polyamides have been achieved by solid-phase and solution-phase methods. A rapid solution-phase...

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Detalhes bibliográficos
Main Authors: Chenoweth, David M., Harki, Daniel A., Dervan, Peter B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736337/
https://ncbi.nlm.nih.gov/pubmed/19627138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol901311m
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