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Py-Im Polyamides Distinguish Double Helical DNA and RNA
[Image: see text] Groove specificity. Pyrrole-imidazole polyamides are well-known for their specific interactions with the minor groove of DNA. Here we demonstrate that polyamides do not similarly bind duplex RNA, and offer a structural rationale for the molecular-level discrimination of nucleic aci...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535541/ https://ncbi.nlm.nih.gov/pubmed/22987334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201205775 |
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