Pharmacokinetics of Py-Im Polyamides Depend on Architecture: Cyclic versus Linear

The pharmacokinetic properties of three pyrrole-imidazole polyamides of similar size and Py-Im content but different shape were studied in mouse. Remarkably, hairpin and cyclic oligomers programmed for the same DNA sequence 5’-WGGWWW-3’ displayed distinct pharmacokinetic properties. Furthermore, the...

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Bibliographic Details
Main Authors:	Raskatov, Jevgenij A., Hargrove, Amanda E., So, Alex Y., Dervan, Peter B.
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3349014/ https://ncbi.nlm.nih.gov/pubmed/22509786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja302588v
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Pharmacokinetics of Py-Im Polyamides Depend on Architecture: Cyclic versus Linear

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