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Pharmacokinetics of Py-Im Polyamides Depend on Architecture: Cyclic versus Linear
The pharmacokinetic properties of three pyrrole-imidazole polyamides of similar size and Py-Im content but different shape were studied in mouse. Remarkably, hairpin and cyclic oligomers programmed for the same DNA sequence 5’-WGGWWW-3’ displayed distinct pharmacokinetic properties. Furthermore, the...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3349014/ https://ncbi.nlm.nih.gov/pubmed/22509786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja302588v |
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