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Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
p53 limits the proliferation of primary diploid fibroblasts by inducing a state of growth arrest named replicative senescence — a process which protects against oncogenic transformation and requires integrity of the p53 tumour suppressor pathway1–3. However, little is known about the downstream targ...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2954492/ https://ncbi.nlm.nih.gov/pubmed/16862142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1448 |
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