ING2 Regulates the Onset of Replicative Senescence by Induction of p300-Dependent p53 Acetylation

ING2 is a candidate tumor suppressor gene that can activate p53 by enhancing its acetylation. Here, we demonstrate that ING2 is also involved in p53-mediated replicative senescence. ING2 protein expression increased in late-passage human primary cells, and it colocalizes with serine 15-phosphorylate...

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Autori principali: Pedeux, Remy, Sengupta, Sagar, Shen, Jiang Cheng, Demidov, Oleg N., Saito, Shin'ichi, Onogi, Hitoshi, Kumamoto, Kensuke, Wincovitch, Stephen, Garfield, Susan H., McMenamin, Mary, Nagashima, Makoto, Grossman, Steven R., Appella, Ettore, Harris, Curtis C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190357/
https://ncbi.nlm.nih.gov/pubmed/16024799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.15.6639-6648.2005
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