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p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2
The tumor suppressor p53 is activated in response to many types of cellular and environmental insults via mechanisms involving post-translational modification. Here we demonstrate that, unlike phosphorylation, p53 invariably undergoes acetylation in cells exposed to a variety of stress-inducing agen...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC145533/ https://ncbi.nlm.nih.gov/pubmed/11250899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.6.1331 |
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