p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2

The tumor suppressor p53 is activated in response to many types of cellular and environmental insults via mechanisms involving post-translational modification. Here we demonstrate that, unlike phosphorylation, p53 invariably undergoes acetylation in cells exposed to a variety of stress-inducing agen...

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Bibliografiske detaljer

Udgivet i:	EMBO J
Principais autores:	Ito, Akihiro, Lai, Chun-Hsiang, Zhao, Xuan, Saito, Shin’ichi, Hamilton, Maria H., Appella, Ettore, Yao, Tso-Pang
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2001
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145533/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11250899/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.6.1331
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