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Transforming Growth Factor-β Requires Its Target Plasminogen Activator Inhibitor-1 for Cytostatic Activity

The cytokine transforming growth factor β (TGFβ) has strong antiproliferative activity in most normal cells but contributes to tumor progression in the later stages of oncogenesis. It is not fully understood which TGFβ target genes are causally involved in mediating its cytostatic activity. We repor...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kortlever, Roderik M., Nijwening, Jeroen H., Bernards, René
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259838/
https://ncbi.nlm.nih.gov/pubmed/18614541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803341200
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