A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)–p53 signaling

Senescence limits the proliferative capacity of primary cells in culture. We describe here a genetic screen to identify genes that allow bypass of this checkpoint. Using retroviral cDNA expression libraries, we identify BCL6 as a potent inhibitor of senescence. BCL6 is frequently activated in non-Ho...

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Detalhes bibliográficos
Main Authors: Shvarts, Avi, Brummelkamp, Thijn R., Scheeren, Ferenc, Koh, Eugene, Daley, George Q., Spits, Hergen, Bernards, René
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2002
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC155362/
https://ncbi.nlm.nih.gov/pubmed/11914273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.929302
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