Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia

Tumor-induced immune defects can weaken host immune response and permit tumor cell growth. In a systemic model of murine acute myeloid leukemia (AML), tumor progression resulted in increased regulatory T cells (Treg) and elevation of program death-1 (PD-1) expression on CD8(+) cytotoxic T cells (CTL...

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Hauptverfasser: Zhou, Qing, Munger, Meghan E., Highfill, Steven L., Tolar, Jakub, Weigel, Brenda J., Riddle, Megan, Sharpe, Arlene H., Vallera, Daniel A., Azuma, Miyuki, Levine, Bruce L., June, Carl H., Murphy, William J., Munn, David H., Blazar, Bruce R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2010
Schlagworte:
Immunobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953885/
https://ncbi.nlm.nih.gov/pubmed/20570856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-275446
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