Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia

Tumor-induced immune defects can weaken host immune response and permit tumor cell growth. In a systemic model of murine acute myeloid leukemia (AML), tumor progression resulted in increased regulatory T cells (Treg) and elevation of program death-1 (PD-1) expression on CD8(+) cytotoxic T cells (CTL...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhou, Qing, Munger, Meghan E., Highfill, Steven L., Tolar, Jakub, Weigel, Brenda J., Riddle, Megan, Sharpe, Arlene H., Vallera, Daniel A., Azuma, Miyuki, Levine, Bruce L., June, Carl H., Murphy, William J., Munn, David H., Blazar, Bruce R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2010
Konular:
Immunobiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953885/
https://ncbi.nlm.nih.gov/pubmed/20570856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-275446
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