Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia

Tumor-induced immune defects can weaken host immune response and permit tumor cell growth. In a systemic model of murine acute myeloid leukemia (AML), tumor progression resulted in increased regulatory T cells (Treg) and elevation of program death-1 (PD-1) expression on CD8(+) cytotoxic T cells (CTL...

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Main Authors: Zhou, Qing, Munger, Meghan E., Highfill, Steven L., Tolar, Jakub, Weigel, Brenda J., Riddle, Megan, Sharpe, Arlene H., Vallera, Daniel A., Azuma, Miyuki, Levine, Bruce L., June, Carl H., Murphy, William J., Munn, David H., Blazar, Bruce R.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2010
Teme:
Immunobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953885/
https://ncbi.nlm.nih.gov/pubmed/20570856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-275446
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