BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

Polycomb group (PcG) proteins are major determinants of cell identity, stem cell pluripotency, and epigenetic gene silencing during development. The polycomb repressive complex 1, which contains BMI1, RING1, and RING2, functions as an E3-ubuiquitin ligase. We found that BMI1 and RING2 are recruited...

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Main Authors: Ismail, Ismail Hassan, Andrin, Christi, McDonald, Darin, Hendzel, Michael J.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2010
主題:
Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953429/
https://ncbi.nlm.nih.gov/pubmed/20921134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201003034
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