A Small Molecule Inhibitor of Polycomb Repressive Complex 1 Inhibits Ubiquitin Signaling at DNA Double-strand Breaks

Polycomb-repressive complex 1 (PRC1)-mediated histone ubiquitylation plays an important role in aberrant gene silencing in human cancers and is a potential target for cancer therapy. Here we show that 2-pyridine-3-yl-methylene-indan-1,3-dione (PRT4165) is a potent inhibitor of PRC1-mediated H2A ubiq...

Full description

Saved in:
Bibliographic Details
Main Authors: Ismail, Ismail Hassan, McDonald, Darin, Strickfaden, Hilmar, Xu, Zhizhong, Hendzel, Michael J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772243/
https://ncbi.nlm.nih.gov/pubmed/23902761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.461699
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items