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Strain-Specific Differences in the Impact of Human TRIM5α, Different TRIM5α Alleles, and the Inhibition of Capsid-Cyclophilin A Interactions on the Infectivity of HIV-1

HIV-1 infectivity is strongly restricted by TRIM5α from certain primate species but has been described as being only marginally susceptible to human TRIM5α. In this study, we evaluated the effects of the modulation of human TRIM5α activity (pretreatment of target cells with alpha interferon, express...

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Autors principals: Battivelli, Emilie, Lecossier, Denise, Matsuoka, Saori, Migraine, Julie, Clavel, François, Hance, Allan J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953162/
https://ncbi.nlm.nih.gov/pubmed/20702630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00758-10
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