Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

PDE7 inhibitors regulate pro-inflammatory and immune T-cell functions, and are a potentially novel class of drugs especially useful in the treatment of a wide variety of immune and inflammatory disorders. Starting from our lead family of thioxoquinazolines, we designed, synthesized, and characterize...

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Détails bibliographiques
Auteurs principaux: Castaño, Tania, Wang, Huanchen, Campillo, Nuria E., Ballester, Sara, González-García, Coral, Hernández, Javier, Pérez, Concepción, Cuenca, Jimena, Pérez-Castillo, Ana, Martínez, Ana, Huertas, Oscar, Gelpí, José Luis, Luque, F. Javier, Ke, Hengming, Gil, Carmen
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952885/
https://ncbi.nlm.nih.gov/pubmed/19350606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200900043
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