Specification of the NF-κB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKKε

Here we investigated the regulation of NF-κB activity by post-translational modifications upon reconstitution of NF-κB p65-deficient cells with the wild-type protein or phosphorylation-defect mutants. Analysis of NF-κB target gene expression showed that p65 phosphorylations alone or in combination f...

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Bibliographic Details
Main Authors: Moreno, Rita, Sobotzik, Jürgen-Markus, Schultz, Christian, Schmitz, M. Lienhard
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952868/
https://ncbi.nlm.nih.gov/pubmed/20507904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq439
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