Glycosaminoglycan-binding properties and kinetic characterization of human heparin cofactor II expressed in Escherichia coli

Irreversible inactivation of α-thrombin (T) by the serpin, heparin cofactor II (HCII), is accelerated by ternary complex formation with the glycosaminoglycans (GAGs) heparin and dermatan sulfate (DS). Low expression of human HCII in Escherichia coli was optimized by silent mutation of 27 rare codons...

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Detaylı Bibliyografya
Asıl Yazarlar: Sarilla, Suryakala, Habib, Sally Y., Tollefsen, Douglas M., Friedman, David B., Arnett, Diana R., Verhamme, Ingrid M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952836/
https://ncbi.nlm.nih.gov/pubmed/20670608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2010.07.024
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