Mutant INS-Gene Induced Diabetes of Youth: Proinsulin Cysteine Residues Impose Dominant-Negative Inhibition on Wild-Type Proinsulin Transport

Recently, a syndrome of Mutant I NS-gene-induced Diabetes of Youth (MIDY, derived from one of 26 distinct mutations) has been identified as a cause of insulin-deficient diabetes, resulting from expression of a misfolded mutant proinsulin protein in the endoplasmic reticulum (ER) of insulin-producing...

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Main Authors: Liu, Ming, Haataja, Leena, Wright, Jordan, Wickramasinghe, Nalinda P., Hua, Qing-Xin, Phillips, Nelson F., Barbetti, Fabrizio, Weiss, Michael A., Arvan, Peter
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952628/
https://ncbi.nlm.nih.gov/pubmed/20948967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013333
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