Cryptochrome Mediates Circadian Regulation of cAMP Signaling and Hepatic Gluconeogenesis

During fasting, mammals maintain glucose homeostasis by stimulating hepatic gluconeogenesis1. Elevations in circulating glucagon (GLU) and epinephrine trigger the cAMP mediated phosphorylation of Creb and dephosphorylation of the Creb coactivator Crtc22. Although the underlying mechanism is unclear,...

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Autori principali: Zhang, Eric E., Liu, Yi, Dentin, Renaud, Pongsawakul, Pagkapol Y., Liu, Andrew C., Hirota, Tsuyoshi, Nusinow, Dmitri A., Sun, Xiujie, Landais, Severine, Kodama, Yuzo, Brenner, David A., Montminy, Marc, Kay, Steve A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952072/
https://ncbi.nlm.nih.gov/pubmed/20852621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2214
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