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Asymmetric Hydrophosphylation of Chiral N-Phosphonyl Imines Provides an Efficient Approach to Chiral α-Amino Phosphonates

Chiral N-phosphonylimines were found to react with lithium phosphites to provide various substituted chiral α-amino phosphonates in excellent yields (94–97%) and diastereoselectivities (93:7 to 99:1). The types of bases utilized for generating the nucleophile are crucial for the effectiveness of asy...

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Autori principali: Kaur, Parminder, Wever, Walter, Rajale, Trideep, Li, Guigen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951300/
https://ncbi.nlm.nih.gov/pubmed/20887612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2010.01013.x
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