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Chiral N-Phosphonyl Imine Chemistry: Asymmetric Additions of Ester Enolates for the Synthesis of β-Amino Acids

Chiral phosphonyl imines attached by 1-naphthyl protection group were found to react with lithium ester enolates smoothly and give chiral β-amino esters in good yields (70−88%) and up to excellent diastereoselectivity (>99:1 dr). Triisopropoxytitanium (IV) chloride was found to enhance diastereos...

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Библиографические подробности
Главные авторы: Han, Jianlin, Ai, Teng, Nguyen, Thao, Li, Guigen
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575089/
https://ncbi.nlm.nih.gov/pubmed/18631372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2008.00682.x
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