Synthesis of chiral N-phosphinyl α-imino esters and their application in asymmetric synthesis of α-amino esters by reduction

A variety of chiral N-phosphinyl α-imino esters have been synthesized for the first time from ketoesters and phosphinylamide, which were then reduced by L-selectride to give the corresponding N-phosphinyl-protected α-amino esters. The reduction proceeded very well with excellent chemical yields (88–...

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Bibliographic Details
Main Authors: Xiong, Yiwen, Mei, Haibo, Wu, Lingmin, Han, Jianlin, Pan, Yi, Li, Guigen
Format: Artigo
Language:Inglês
Published: Beilstein-Institut 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3999852/
https://ncbi.nlm.nih.gov/pubmed/24778716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.10.57
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