Spatiotemporal regulation of T cell co-stimulation by TCR-CD28 microclusters through PKCθ translocation

T cell activation is mediated by microclusters (MCs) containing TCRs, kinases, and adaptors. Although TCR-MCs translocate to form a central supramolecular activation cluster (c-SMAC) of immunological synapse between T cells and antigen-presenting cells (APCs), the role of MC translocation in T cell...

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Main Authors: Yokosuka, Tadashi, Kobayashi, Wakana, Sakata-Sogawa, Kumiko, Hashimoto-Tane, Akiko, Dustin, Michel L., Tokunaga, Makio, Saito, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950619/
https://ncbi.nlm.nih.gov/pubmed/18848472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.08.011
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