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Translational and basic applications of peptide-MHCI single chain trimers

MHC class I molecules can be engineered as single chain trimers (SCT) that sequentially incorporate all three subunits of the fully assembled proteins, namely peptide, β2m, and heavy chain. SCTs have been made with many different MHC-peptide complexes and are used as novel diagnostic and therapeutic...

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Detalhes bibliográficos
Main Authors: Hansen, Ted H., Connolly, Janet M., Gould, Keith G., Fremont, Daved H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949479/
https://ncbi.nlm.nih.gov/pubmed/20832361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2010.07.003
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