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Amino-Terminal Extended Peptide Single-Chain Trimers are Potent Synthetic Agonists for Memory Human CD8+ T cells

Upon antigen exposure, most memory T cells undergo re-stimulation induced cell death. Here we describe a novel synthetic agonist, an amino-terminal extended decamer peptide expressed as a single chain trimer, the AT-SCT, that preferentially promotes the growth of memory human CD8+ T cells with minim...

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Detalhes bibliográficos
Main Authors: Carreno, Beatriz M., Becker-Hapak, Michelle, Chan, Megan, Lie, Wen-Rong, Wang, Xiaoli, Hansen, Ted H., Linette, Gerald P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370155/
https://ncbi.nlm.nih.gov/pubmed/22573808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103647
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