Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation

The farnesoid X receptor (FXR), a member of the nuclear hormone receptor family, plays important roles in the regulation of bile acid and cholesterol homeostasis, glucose metabolism, and insulin sensitivity. There is intense interest in understanding the mechanisms of FXR regulation and in developin...

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Bibliografiske detaljer
Main Authors: Soisson, Stephen M., Parthasarathy, Gopalakrishnan, Adams, Alan D., Sahoo, Soumya, Sitlani, Ayesha, Sparrow, Carl, Cui, Jisong, Becker, Joseph W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291122/
https://ncbi.nlm.nih.gov/pubmed/18391212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710981105
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