Synthetic FXR Agonist GW4064 Is a Modulator of Multiple G Protein–Coupled Receptors

The synthetic nuclear bile acid receptor (farnesoid X receptor [FXR]) agonist GW4064 is extensively used as a specific pharmacological tool to illustrate FXR functions. We noticed that GW4064 activated empty luciferase reporters in FXR-deficient HEK-293T cells. We postulated that this activity of GW...

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Dettagli Bibliografici
Pubblicato in:Mol Endocrinol
Autori principali: Singh, Nidhi, Yadav, Manisha, Singh, Abhishek Kumar, Kumar, Harish, Dwivedi, Shailendra Kumar Dhar, Mishra, Jay Sharan, Gurjar, Anagha, Manhas, Amit, Chandra, Sharat, Yadav, Prem Narayan, Jagavelu, Kumaravelu, Siddiqi, Mohammad Imran, Trivedi, Arun Kumar, Chattopadhyay, Naibedya, Sanyal, Sabyasachi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2014
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414852/
https://ncbi.nlm.nih.gov/pubmed/24597548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2013-1353
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