Exposure to the synthetic FXR agonist GW4064 causes alterations in gene expression and sublethal hepatotoxicity in eleutheroembryo medaka (Oryzias latipes)

The small freshwater teleost, medaka (Oryzias latipes), has a history of usage in studies of chronic toxicity of liver and biliary system. Recent progress with this model has focused on defining the medaka hepatobiliary system. Here we investigate critical liver function and toxicity by examining th...

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Detalhes bibliográficos
Main Authors: Howarth, Deanna L., Law, Sheran H.W., Law, J. McHugh, Mondon, J.A., Kullman, Seth W., Hinton, David E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853180/
https://ncbi.nlm.nih.gov/pubmed/19963001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2009.11.022
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