Synthetic FXR Agonist GW4064 Is a Modulator of Multiple G Protein–Coupled Receptors

The synthetic nuclear bile acid receptor (farnesoid X receptor [FXR]) agonist GW4064 is extensively used as a specific pharmacological tool to illustrate FXR functions. We noticed that GW4064 activated empty luciferase reporters in FXR-deficient HEK-293T cells. We postulated that this activity of GW...

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Detalhes bibliográficos
Publicado no:Mol Endocrinol
Main Authors: Singh, Nidhi, Yadav, Manisha, Singh, Abhishek Kumar, Kumar, Harish, Dwivedi, Shailendra Kumar Dhar, Mishra, Jay Sharan, Gurjar, Anagha, Manhas, Amit, Chandra, Sharat, Yadav, Prem Narayan, Jagavelu, Kumaravelu, Siddiqi, Mohammad Imran, Trivedi, Arun Kumar, Chattopadhyay, Naibedya, Sanyal, Sabyasachi
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414852/
https://ncbi.nlm.nih.gov/pubmed/24597548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2013-1353
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