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Sulfated Dextrans Enhance In Vitro Amplification of Bovine Spongiform Encephalopathy PrP(Sc) and Enable Ultrasensitive Detection of Bovine PrP(Sc)
BACKGROUND: Prions, infectious agents associated with prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy (BSE) in cattle, and scrapie in sheep and goats, are primarily comprised of PrP(Sc), a protease-resistant misfolded isoform of the cellular prion protein...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2949392/ https://ncbi.nlm.nih.gov/pubmed/20957174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013152 |
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