Sulfated Dextrans Enhance In Vitro Amplification of Bovine Spongiform Encephalopathy PrP(Sc) and Enable Ultrasensitive Detection of Bovine PrP(Sc)

BACKGROUND: Prions, infectious agents associated with prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy (BSE) in cattle, and scrapie in sheep and goats, are primarily comprised of PrP(Sc), a protease-resistant misfolded isoform of the cellular prion protein...

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Main Authors: Murayama, Yuichi, Yoshioka, Miyako, Masujin, Kentaro, Okada, Hiroyuki, Iwamaru, Yoshifumi, Imamura, Morikazu, Matsuura, Yuichi, Fukuda, Shigeo, Onoe, Sadao, Yokoyama, Takashi, Mohri, Shirou
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949392/
https://ncbi.nlm.nih.gov/pubmed/20957174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013152
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