Generation of Human Antigen-Specific Monoclonal IgM Antibodies Using Vaccinated “Human Immune System” Mice

BACKGROUND: Passive transfer of antibodies not only provides immediate short-term protection against disease, but also can be exploited as a therapeutic tool. However, the ‘humanization’ of murine monoclonal antibodies (mAbs) is a time-consuming and expensive process that has the inherent drawback o...

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Detalhes bibliográficos
Main Authors: Becker, Pablo D., Legrand, Nicolas, van Geelen, Caroline M. M., Noerder, Miriam, Huntington, Nicholas D., Lim, Annick, Yasuda, Etsuko, Diehl, Sean A., Scheeren, Ferenc A., Ott, Michael, Weijer, Kees, Wedemeyer, Heiner, Di Santo, James P., Beaumont, Tim, Guzman, Carlos A., Spits, Hergen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949385/
https://ncbi.nlm.nih.gov/pubmed/20957227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013137
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