Generation of Human Antigen-Specific Monoclonal IgM Antibodies Using Vaccinated “Human Immune System” Mice

BACKGROUND: Passive transfer of antibodies not only provides immediate short-term protection against disease, but also can be exploited as a therapeutic tool. However, the ‘humanization’ of murine monoclonal antibodies (mAbs) is a time-consuming and expensive process that has the inherent drawback o...

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Hauptverfasser: Becker, Pablo D., Legrand, Nicolas, van Geelen, Caroline M. M., Noerder, Miriam, Huntington, Nicholas D., Lim, Annick, Yasuda, Etsuko, Diehl, Sean A., Scheeren, Ferenc A., Ott, Michael, Weijer, Kees, Wedemeyer, Heiner, Di Santo, James P., Beaumont, Tim, Guzman, Carlos A., Spits, Hergen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949385/
https://ncbi.nlm.nih.gov/pubmed/20957227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013137
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