Antigen-Specific Monoclonal Antibodies Isolated from B Cells Expressing Constitutively Active STAT5

BACKGROUND: Fully human monoclonal antibodies directed against specific pathogens have a high therapeutic potential, but are difficult to generate. METHODOLOGY/PRINCIPAL FINDINGS: Memory B cells were immortalized by expressing an inducible active mutant of the transcription factor Signal Transducer...

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Main Authors: Scheeren, Ferenc A., van Geelen, Caroline M. M., Yasuda, Etsuko, Spits, Hergen, Beaumont, Tim
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078118/
https://ncbi.nlm.nih.gov/pubmed/21525985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017189
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