Generation of Human Antigen-Specific Monoclonal IgM Antibodies Using Vaccinated “Human Immune System” Mice

BACKGROUND: Passive transfer of antibodies not only provides immediate short-term protection against disease, but also can be exploited as a therapeutic tool. However, the ‘humanization’ of murine monoclonal antibodies (mAbs) is a time-consuming and expensive process that has the inherent drawback o...

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Bibliografiske detaljer
Main Authors: Becker, Pablo D., Legrand, Nicolas, van Geelen, Caroline M. M., Noerder, Miriam, Huntington, Nicholas D., Lim, Annick, Yasuda, Etsuko, Diehl, Sean A., Scheeren, Ferenc A., Ott, Michael, Weijer, Kees, Wedemeyer, Heiner, Di Santo, James P., Beaumont, Tim, Guzman, Carlos A., Spits, Hergen
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949385/
https://ncbi.nlm.nih.gov/pubmed/20957227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013137
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